Principal Scientist, Proteomics

Pfizer, Inc.

La Jolla, CA


Pfizer’s Oncology Research Division is dedicated to the development of oncology agents that disrupt cancer biology or redirect the immune system against cancer cells.

As a Principal Scientist in Proteomics, your research will drive a deeper understanding of ADCs including novel payloads, tumor-associated antigens, and immune engagers. Relevant proteomic methodologies include label-free and TMT mass spectrometry, and profiling protein abundance, turnover, and interactomes.

You will represent the Systems Biology group on research and drug discovery teams, and will work closely with line leads in biology, chemical biology, drug design, and protein engineering groups to innovate and develop first-in-class oncology therapies.


  • Contribute as a proteomics team lead including line leadership within research project teams, developing and deploying new technologies, and manage junior colleagues.

  • Drive innovation in all aspects of laboratory operations including mass spec technology evaluation, proteomic software evaluation, development of quantitative sample preparation methods and peptide separation methods, data analysis and interpretation.

  • Enhance the external reputation of Pfizer’s Systems Biology through establish research collaborations, presenting at conferences, and contributing publications.


  • Ph.D. in biological sciences, proteomics, chemical biology, analytical chemistry, or a related field

  • 4+ years related industry R&D experience

  • Experience leading a small team

  • Applied mass spectrometry-based proteomics experience including experience with Thermo Tribrid Orbitraps.

  • Expertise with targeted mass spectrometry (parallel reaction monitoring; PRM), data independent acquisition (DIA), and/or tandem mass tag (TMT) methods.

  • Strong verbal and written communication skills.


  • 6+ years of related industry and/or postdoctoral experience

  • Experience with ZenoTOF or timsTOF

  • Deep understanding of automated sample prep, chemoproteomics, targeted biologics, and small-molecule degraders.

  • Knowledge of oncology including cytotoxins, kinase inhibitors, molecular glues, CD3 bispecifics, and immune-oncology.

Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.

Relocation support available

Work Location Assignment: On Premise

The annual base salary for this position ranges from $99,900.00 to $166,500.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 15.0% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | ( Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Sunshine Act

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EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.

Research and Development ID:uDnQdo