Computational ADME Scientist

Pfizer, Inc.

Groton, CT

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As the world’s leading pharmaceutical company, Pfizer is in the unique position of having some of the largest and most complex chemical and biological data sets available anywhere. The computational Absorption, Distribution, Metabolism, and Excretion (cADME) group at Pfizer is responsible for maximizing the value of ADME, safety, and pharmacology data to support drug discovery project teams. We do this through the application of advanced machine learning and data mining methodologies to extract knowledge that is used to facilitate project team decision making across the drug discovery portfolio.

We are looking to add an outstanding and experienced cADME scientist to develop novel in silico tools, methodologies, and infrastructure for data mining, machine learning, and visualization. These approaches will be used to extract actionable information and knowledge from Pfizer’s chemical and biological databases.

Minimum Experience

  • Ph.D. with at least two years or equivalent experience in computational ADME, cheminformatics, scientific programming, machine learning, statistics, computational chemistry, computational biology, or a related discipline.

  • Demonstrated experience with an advanced programming language for analysis (e.g. Python, R, Java).

  • Demonstrated ability to independently develop and implement complex computational solutions to data mining and analysis problems.

  • Ability to build and interpret machine learning models of complex, high-dimensional systems.

  • Ability to work with incomplete or imperfect data to extract usable information.

  • Demonstrated proficiency in working with databases, web-based applications, and other information technology tools.

  • Highly self-motivated, results driven, and data driven. Ability to work in a fast-paced dynamic environment.

  • Track record of demonstrating personal leadership and the ability to influence stakeholders to gain support and traction for projects.

  • Skilled in clearly and concisely communicating, both oral and written, complex computational approaches and methodology to non-computational scientists and other stakeholders.

Desired Experience

  • Demonstrated experience using machine learning/cheminformatics to guide drug discovery project teams and medicinal chemists.

  • Sound understanding of organic/medicinal chemistry.

  • Experience with ADME and/or Primary Pharmacology biology and science.

  • Experience with the application of 3D computational methods including pharmacophore modeling, QM calculations, and protein-ligand docking.


Sitting, ability to perform mathematical calculations and complex data analysis


Occasional Travel

Relocation support available

Work Location Assignment: Flexible

Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

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