Scientist, Upstream Process Development

Bristol-Myers Squibb Company

Devens, MA

Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more:

Business Unit Overview

Our Biologics Development team is responsible for development and transfer of safe, efficient, and approvable biologics drug substance manufacturing processes and analytical methods for all of BMS’ biologics portfolio. We work closely with other BMS units to support our clinical pipeline through to late stages of clinical development. Innovation is at the core of what we do, with an intense focus on efficiency, speed, robustness, and approvability of our processes and methods. Here, you’ll get the chance through opportunities uncommon in scale and scope, pursue innovative ideas, and advance professionally alongside some of the brightest minds in Biopharma.

Position Summary

We are seeking an Upstream Process Development Scientist to join our Biologics Development group as part of the broader GUCLD (Global Upstream and Cell Line Development) organization. This position participates in fundamental areas such as clone selection, platform fit, process optimization, process characterization, scale-up and tech transfer to clinical manufacturing. The group’s function also includes continued platform evolution and technology development efforts. The environment is highly collaborative and matrixed with colleagues in cell line, downstream, analytical groups as well as with manufacturing, and MS&T organizations. This position will be responsible for conceptualizing, supporting and leading upstream development projects. Responsibilities include scientific presentations and authoring high quality technical reports as well as support of regulatory filings. This position offers the successful candidate many opportunities to learn and grow their career in biologics process development.

Key Responsibilities

  • Collaborate within a team to develop high-performance upstream processes for recombinant protein production inclusive of monoclonal antibodies, complex fusion proteins, bi-specific antibodies, antibody drug conjugates (ADC) as well as AAV triple transient transfection production processes
  • Establish robust upstream process platform as well as a toolbox for both early and late-stage programs, and collaborate closely with cell line development, downstream process development and analytical groups to streamline overall workflows
  • Apply Quality by Design (QbD) principles as appropriate in process development and characterizations, and jointly develop suitable control strategies for commercial processing
  • Support tech transfer activities to pilot scale and clinical manufacturing operations (both internal and externally to CMOs), perform risk assessment, develop appropriate mitigation strategies, and provide PIP support for manufacturing activities and troubleshooting efforts as needed
  • Participate as a DS upstream representative in cross-functional CMC teams to advance programs in a timely manner
  • Identify and evaluate new technologies and applications, drive external collaborations to improve processes, develop appropriate IP strategies to ensure freedom to operate, and pursue patent opportunities
  • Present technical summaries to peers and upper management as well as technical writing for development reports, and regulatory filing support
  • Publish or present scientific findings in peer-reviewed journals or conferences, and participate in industrial collaborations
  • Provide supervision and mentorship to junior scientists

Qualifications & Experience

  • Ph.D. in Chemical Engineering, Biological Sciences, or relevant disciplines with 0-2 years of relevant industrial experience; MS with 4+ years relevant industrial experience; or BS with 6+ years relevant industrial experience
  • Proven track record of accomplishments in the design, development, and implementation of industrial mammalian cell culture processes for recombinant protein production
  • Knowledge and/or experience with more complex proteins (fusion proteins, ADCs, etc.), as well as cell and gene therapy processes and principles is desired
  • Hands-on experience with upstream laboratory activities including the operation of high throughput mini-bioreactors and familiarity with pilot/manufacturing scale single-use bioreactor systems
  • Knowledge of bioreactor characterization and engineering principles affecting scale-up (mass transfer, mixing, shear, etc.) as well as robust understanding of biochemistry and cell metabolic pathways
  • Specialized experience in one or more areas as applied to mammalian upstream process development, examples include: media development, cell and protein analysis techniques, omics techniques, relevant application of statistics / DoE, machine learning, gene therapy / AAV production processes, etc.
  • Demonstrated ability identifying and evaluating new technologies to accelerate upstream process development and improve process efficiency
  • Ability to troubleshoot, solve problems and think critically
  • Basic understanding of bioprocessing in a GMP environment
  • Demonstrated experience of strong performance working both independently and in team settings
  • Strong project leadership and excellent resource management skills
  • Excellent verbal and written communication skills

If you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as “Transforming patients’ lives through science™ ”, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

On-site Protocol
Physical presence at the BMS worksite or physical presence in the field is a necessary job function of this role, which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and it enhances the Company culture.

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to Visit to access our complete Equal Employment Opportunity statement.

BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.

BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.