Sr. Director – Directed Tumor Killing

Gilead Sciences, Inc.

Foster City, CA

For Current Gilead Employees and Contractors:

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At Gilead we believe every employee deserves a great leader. As a people leader now or in the future, we expect that you will model and create an environment of inclusion, be intentionally focused on the hiring, development, growth and retention of talent, and empower teams to align and achieve goals.

Job Description

The Oncology Research department at Gilead Sciences is seeking an exceptional and highly motivated Sr. Director to oversee a research group focused on development of antibody-drug conjugates (ADCs) and other methods of directed tumor killing for the treatment of cancers with high unmet medical need. The successful candidate will provide scientific and technical expertise in efforts to elucidate the mechanism of action (MOA) of ADCs and other large molecule therapeutics and to generate the rationale for novel therapeutic combinations that induce tumor killing and result in durable anti-tumor responses, aiming to guide therapeutic combinations in clinical oncology settings. The candidate will lead internal projects and external collaborations to identify and deliver drug candidates that warrant clinical evaluation and will support Gilead’s Business Development team in evaluating external partnership opportunities. The position has ample opportunities for career growth through acquisition of new skills, experiences, and professional relationships in an inclusive, fast-paced, and resource-rich environment.

Key Responsibilities

  • Oversee a portfolio of discovery and peri-IND research programs to advance novel oncology therapeutics towards the clinic, emphasizing ADCs and other large molecule targeted therapies capable of mediating tumor cell killing.

  • Manage a highly productive team of Research Associates and Scientists to initiate and advance pre-clinical programs. Train and mentor junior scientists.

  • Provide leadership to and collaboration with multi-disciplinary project teams to discover and develop large molecule targeted therapies and understand combination potential. Proactively identify project risks and effectively communicate to project teams and leadership.

  • Manage multiple programs simultaneously and work cross-functionally with colleagues in oncology, protein engineering, chemistry, safety/toxicology, clinical development and other functions to advance programs. Ensure timely delivery of biology data to support key decision-making.

  • Think critically and creatively, emphasize rapid data-driven decision-making that balances risk-taking with rigorous go/no-go experiments to prosecute and promote a differentiated pre-clinical pipeline.

  • Contribute expertise to multi-disciplinary externally facing teams to evaluate and recommend partnerships and acquisitions

  • Lead joint internal/external teams to discover novel therapeutics, understand mode of action and therapeutic potential of novel drug candidates

Knowledge, Experience and Skills

  • PhD degree with post-doctoral research experience and 10+ years of experience in immunology, cancer biology, and/or cell biology with previous experience in drug discovery and MOA studies

  • Extensive knowledge base in antibody-drug conjugate development, with preferred experience in immunology and/or cancer immunotherapy, and a strong track record of past achievements

  • Ability to challenge the status-quo and propose highly innovative approaches to key questions in the field

  • Excellent communication and interpersonal skills with ability to summarize complex scientific questions and biological processes for non-experts

  • Ability to identify and communicate key issues, bottlenecks, and risks that could impact the business while facilitating solutions and mitigations

  • Proven managerial excellence and ability to motivate highly skilled team members from diverse backgrounds

  • Team mindset

The salary range for this position is: $230,860.00 - $298,760.00. Gilead considers a variety of factors when determining base compensation, including experience, qualifications, and geographic location. These considerations mean actual compensation will vary. This position may also be eligible for a discretionary annual bonus, discretionary stock-based long-term incentives (eligibility may vary based on role), paid time off, and a benefits package. Benefits include company-sponsored medical, dental, vision, and life insurance plans*.

For additional benefits information, visit:

* Eligible employees may participate in benefit plans, subject to the terms and conditions of the applicable plans.

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For Current Gilead Employees and Contractors:

Please log onto your Internal Career Site to apply for this job.